ea0004p34 | Cytokines and growth factors | SFE2002
Ogunkolade B
, Kelly|P##
, S##Khalaf P
, Fairclough P
, Li R
, Ahmed S
, Hands R
, Bustin S
, Jenkins P
Background:Circulating levels of IGFBP-3 are inversely associated with the risk of developing colorectal cancers (CRC). In addition to modulating IGF bioavailability, IGFBP-3 also exerts independent pro-apoptotic effects. Furthermore, the mode of action of several apoptotic and antiproliferative agents, including vitamin D, has been shown to involve induction of IGFBP-3.Aims:To quantitate and compare IGFBP-3 ...